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THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.90, animal model 0.55, genetic association 0.00, clinical 0.91).
In plain words · THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
THRA (Thyroid hormone receptor alpha) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
No product in this corpus aims at THRA yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA THRA: RNA tissue enriched (brain 401 nTPM); high antibody staining in 9 normal tissues; highest cancer staining testis cancer (2 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Thyroid cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (differentiated thyroid carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas THRA tissue; Open Targets ENSG00000126351 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Pfahl et al, Nucleic Acids Res, 1987, "Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor". Source.
Sources: HGNC HGNC:11796 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10827 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126351 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: thyroid cancer 0.57 (GraphQL API, CC0))
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. Location: Nucleus; Cytoplasm (UniProt). Locus 17q21.1 (HGNC).
RNA: tissue enriched (brain 401 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Appendix, Bone marrow, Breast, Cerebellum, Duodenum, Endometrium.
RNA cancer enhanced: Glioblastoma Multiforme 138 pTPM.
Medium only: cervical cancer, colorectal cancer, endometrial cancer, glioma.
HPA THRA tissue · HPA THRA pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"THRA" OR ABSTRACT:"THRA" OR TITLE:"thyroid hormone receptor alpha" OR ABSTRACT:"thyroid hormone receptor alpha" OR TITLE:"Thyroid hormone receptor alpha" OR ABSTRACT:"Thyroid hormone receptor alpha" OR TITLE:"EAR-7.1/EAR-7.2" OR ABSTRACT:"EAR-7.1/EAR-7.2" OR TITLE:"THRA3" OR ABSTRACT:"THRA3" OR TITLE:"AR7" OR ABSTRACT:"AR7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about THRA, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.