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FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.96, animal model 0.91, genetic association 0.71, genetic literature 0.57).
In plain words · FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription.
No product in this corpus aims at FOXE1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Wiese et al, DNA Cell Biol, 1997, "The novel human HNF-3/fork head-like 5 gene: chromosomal localization and expression pattern". Source.
Sources: HGNC HGNC:3806 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00358 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178919 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: thyroid cancer 0.64 (GraphQL API, CC0))
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. Location: Nucleus (UniProt). Locus 9q22.33 (HGNC).
Query for this target: (TITLE:"FOXE1" OR ABSTRACT:"FOXE1" OR TITLE:"forkhead box E1" OR ABSTRACT:"forkhead box E1" OR TITLE:"Forkhead box protein E1" OR ABSTRACT:"Forkhead box protein E1" OR TITLE:"TTF-2" OR ABSTRACT:"TTF-2" OR TITLE:"HFKH4" OR ABSTRACT:"HFKH4" OR TITLE:"FKHL15" OR ABSTRACT:"FKHL15") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXE1, not a curated reading list.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.