Loading
SDCCAG8 (Serologically defined colon cancer antigen 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signalling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localisation which is critical for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body; Cell junction (UniProt). Locus 1q43-q44 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"SDCCAG8" OR ABSTRACT:"SDCCAG8" OR TITLE:"SHH signaling and ciliogenesis regulator SDCCAG8" OR ABSTRACT:"SHH signaling and ciliogenesis regulator SDCCAG8" OR TITLE:"Serologically defined colon cancer antigen 8" OR ABSTRACT:"Serologically defined colon cancer antigen 8" OR TITLE:"NY-CO-8" OR ABSTRACT:"NY-CO-8" OR TITLE:"CCCAP" OR ABSTRACT:"CCCAP" OR TITLE:"SLSN7" OR ABSTRACT:"SLSN7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDCCAG8, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/sdccag8.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sdccag8.json. Licence CC BY-NC 4.0.