{"entity":{"id":"thrb","kind":"target","name":"THRB","aka":["thyroid hormone receptor beta","Thyroid hormone receptor beta","THRB1","THRB2","NR1A2","THR1","ERBA-BETA","TRbeta","TRb","c-erbA-beta","c-erbA-2","THRbeta","TRbeta1","THRbeta1","Thrbeta2","ERBA2"],"tldr":"THRB (Thyroid hormone receptor beta) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer.","summary":"Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.95, animal model 0.75, genetic association 0.46, clinical 0.91).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11799"},{"label":"UniProt P10828","url":"https://www.uniprot.org/uniprotkb/P10828/entry"},{"label":"NCBI Gene 7068","url":"https://www.ncbi.nlm.nih.gov/gene/7068"},{"label":"Ensembl ENSG00000151090","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151090"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.91. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"THRB","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11799","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10828","url":"https://www.uniprot.org/uniprotkb/P10828/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000151090","url":"https://platform.opentargets.org/target/ENSG00000151090/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: thyroid cancer 0.58 (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA THRB: RNA low tissue specificity; blood lineage group enriched (B-cells 2 nTPM, granulocytes 7 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Thyroid cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (differentiated thyroid carcinoma). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas THRB tissue","url":"https://www.proteinatlas.org/ENSG00000151090-THRB/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000151090 associations","url":"https://platform.opentargets.org/target/ENSG00000151090/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11799","ensembl":"ENSG00000151090","uniprot":"P10828","entrez":"7068","firstDescribed":1986,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Weinberger et al, Cold Spring Harb. Symp. Quant. Biol, 1986, \"Human steroid receptors and erbA proto-oncogene products: members of a new superfamily of enhancer binding proteins\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3034496/","biology":"Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Location: Nucleus (UniProt). Locus 3p24.2 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.58 with thyroid cancer (MONDO_0002108)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/thrb/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}