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NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion. Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation. In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Another study shows only weak behaviour as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR. Location: Cytoplasmic vesicle, autophagosome; Autolysosome; Nucleus; Chromosome (UniProt). Locus 10q11.22 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"NCOA4" OR ABSTRACT:"NCOA4" OR TITLE:"nuclear receptor coactivator 4" OR ABSTRACT:"nuclear receptor coactivator 4" OR TITLE:"Nuclear receptor coactivator 4" OR ABSTRACT:"Nuclear receptor coactivator 4" OR TITLE:"ARA70" OR ABSTRACT:"ARA70" OR TITLE:"ELE1" OR ABSTRACT:"ELE1" OR TITLE:"PTC3" OR ABSTRACT:"PTC3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOA4, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ncoa4.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ncoa4.json. Licence CC BY-NC 4.0.