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STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.
Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.91, genetic association 0.51, somatic mutation 0.96).
In plain words · STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.
STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.
Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes.
No product in this corpus aims at STRN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Moqrich et al, Genomics, 1998, "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Source.
Sources: HGNC HGNC:11424 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43815 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115808 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: thyroid cancer 0.54, lung cancer 0.53 (GraphQL API, CC0))
Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Membrane; Cell projection, dendritic spine (UniProt). Locus 2p22.2 (HGNC).
Query for this target: (TITLE:"STRN" OR ABSTRACT:"STRN" OR TITLE:"striatin" OR ABSTRACT:"striatin" OR TITLE:"Striatin" OR ABSTRACT:"Striatin" OR TITLE:"PPP2R6A" OR ABSTRACT:"PPP2R6A" OR TITLE:"STRN1" OR ABSTRACT:"STRN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STRN, not a curated reading list.
Shares Thyroid cancer, Lung cancer (all types), Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.