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CASP10 (Caspase-10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.74, genetic association 0.52, somatic mutation 0.68, genetic literature 0.61).
In plain words · CASP10 (Caspase-10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
CASP10 (Caspase-10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner.
No product in this corpus aims at CASP10 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1996. Earliest sequence paper UniProt cites for the protein: Fernandes-Alnemri et al, Proc. Natl. Acad. Sci. U.S.A, 1996, "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains". Source.
Sources: HGNC HGNC:1500 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92851 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000003400 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: gastric cancer 0.56, non-Hodgkin lymphoma 0.55 (GraphQL API, CC0))
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyses the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Locus 2q33.1 (HGNC).
Query for this target: (TITLE:"CASP10" OR ABSTRACT:"CASP10" OR TITLE:"caspase 10" OR ABSTRACT:"caspase 10" OR TITLE:"Caspase-10" OR ABSTRACT:"Caspase-10" OR TITLE:"MCH4" OR ABSTRACT:"MCH4" OR TITLE:"FLICE-2" OR ABSTRACT:"FLICE-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CASP10, not a curated reading list.