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CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.19, genetic association 0.00, somatic mutation 0.95).
In plain words · CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites.
No product in this corpus aims at CCNB1IP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2003. Earliest sequence paper UniProt cites for the protein: Toby G.G. et al, Mol. Cell. Biol, 2003, "A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels". Source.
Sources: HGNC HGNC:19437 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NPC3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100814 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: skin cancer 0.51 (GraphQL API, CC0))
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Location: Nucleus; Chromosome (UniProt). Locus 14q11.2 (HGNC).
Query for this target: (TITLE:"CCNB1IP1" OR ABSTRACT:"CCNB1IP1" OR TITLE:"cyclin B1 interacting protein 1" OR ABSTRACT:"cyclin B1 interacting protein 1" OR TITLE:"E3 ubiquitin-protein ligase CCNB1IP1" OR ABSTRACT:"E3 ubiquitin-protein ligase CCNB1IP1" OR TITLE:"HEI10" OR ABSTRACT:"HEI10" OR TITLE:"C14orf18" OR ABSTRACT:"C14orf18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCNB1IP1, not a curated reading list.