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TPCN2 (Two pore channel protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Intracellular channel initially characterised as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localises to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.79, animal model 0.25, genetic association 0.68).
In plain words · TPCN2 (Two pore channel protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
TPCN2 (Two pore channel protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Intracellular channel initially characterised as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate).
No product in this corpus aims at TPCN2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:20820 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NHX9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162341 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: skin cancer 0.50 (GraphQL API, CC0))
Intracellular channel initially characterised as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localises to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis. Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites. Location: Late endosome membrane; Lysosome membrane; Melanosome membrane (UniProt). Locus 11q13.3 (HGNC).
Query for this target: (TITLE:"TPCN2" OR ABSTRACT:"TPCN2" OR TITLE:"two pore segment channel 2" OR ABSTRACT:"two pore segment channel 2" OR TITLE:"Two pore channel protein 2" OR ABSTRACT:"Two pore channel protein 2" OR TITLE:"TPC2" OR ABSTRACT:"TPC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPCN2, not a curated reading list.