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ADRA1B (Alpha-1B adrenergic receptor) is a receptor that reads hormone signals inside the cell nucleus. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.74, animal model 0.52, genetic association 0.05, clinical 0.86).
In plain words · ADRA1B (Alpha-1B adrenergic receptor) is a receptor that reads hormone signals inside the cell nucleus. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
ADRA1B (Alpha-1B adrenergic receptor) is a receptor that reads hormone signals inside the cell nucleus. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11).
No product in this corpus aims at ADRA1B yet. Drugs cut off the hormone supply, block the receptor so the hormone cannot bind, or send the receptor to the cell's waste disposal.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ADRA1B: RNA tissue enhanced (blood vessel 17 nTPM, liver 11 nTPM, lymphoid tissue 11 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Neuroendocrine tumours); Open Targets associates it with 2 specific cancer types at or above 0.5 (benign prostatic hyperplasia, adrenal gland pheochromocytoma); the corpus evidence decides and the Open Targets list is quoted for comparison. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ADRA1B tissue; Open Targets ENSG00000170214 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Ramarao C.S. et al, J. Biol. Chem, 1992, "Genomic organization and expression of the human alpha 1B-adrenergic receptor". Source.
Sources: HGNC HGNC:278 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35368 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000170214 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.52 (GraphQL API, CC0))
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signalling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy. Location: Nucleus membrane; Cell membrane; Cytoplasm; Membrane, caveola (UniProt). Locus 5q33.3 (HGNC).
RNA: tissue enhanced (blood vessel 17 nTPM, liver 11 nTPM, lymphoid tissue 11 nTPM), detected in many normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Kidney Renal Clear Cell Carcinoma 7 pTPM.
No cancer sample stained medium or high.
HPA ADRA1B tissue · HPA ADRA1B pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ADRA1B" OR ABSTRACT:"ADRA1B" OR TITLE:"adrenoceptor alpha 1B" OR ABSTRACT:"adrenoceptor alpha 1B" OR TITLE:"Alpha-1B adrenergic receptor" OR ABSTRACT:"Alpha-1B adrenergic receptor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADRA1B, not a curated reading list.