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FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells.
CIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Sorafenib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.40, affected pathway 0.94, genetic association 0.05).
In plain words · FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
No product in this corpus aims at FGF4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA not detected, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGF4: RNA not detected; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FGF4 tissue; Open Targets ENSG00000075388 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Yoshida et al, Proc. Natl. Acad. Sci. U.S.A, 1987, "Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein". Source.
Sources: HGNC HGNC:3682 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08620 (protein name, function text, keywords and locations (REST API)); CIViC gene FGF4 (4 evidence items, 0 assertions, 2 variants; diseases: Cancer, Hepatocellular Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000075388 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).
RNA: not detected, not detected normal tissues.
No normal tissue stained high.
RNA cancer enriched: Testicular Germ Cell Tumor 20 pTPM.
No cancer stained high; medium in breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FGF4" OR ABSTRACT:"FGF4" OR TITLE:"fibroblast growth factor 4" OR ABSTRACT:"fibroblast growth factor 4" OR TITLE:"Fibroblast growth factor 4" OR ABSTRACT:"Fibroblast growth factor 4" OR TITLE:"K-FGF" OR ABSTRACT:"K-FGF" OR TITLE:"HBGF-4" OR ABSTRACT:"HBGF-4" OR TITLE:"HST-1" OR ABSTRACT:"HST-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF4, not a curated reading list.