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EOMES (Eomesodermin homolog) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex.
Open Targets scores its association with cancer at 0.49 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.60).
In plain words · EOMES (Eomesodermin homolog) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.
EOMES (Eomesodermin homolog) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification.
No product in this corpus aims at EOMES yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Kimura et al, Brain Res. Dev. Brain Res, 1999, "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain". Source.
Sources: HGNC HGNC:3372 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95936 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163508 (association with cancer (MONDO_0004992) 0.49; per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.52 (GraphQL API, CC0))
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Required for differentiation and migration of unipolar dendritic brush cells. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Location: Nucleus (UniProt). Locus 3p24.1 (HGNC).
Query for this target: (TITLE:"EOMES" OR ABSTRACT:"EOMES" OR TITLE:"eomesodermin" OR ABSTRACT:"eomesodermin" OR TITLE:"Eomesodermin homolog" OR ABSTRACT:"Eomesodermin homolog" OR TITLE:"TBR2" OR ABSTRACT:"TBR2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EOMES, not a curated reading list.