Loading
ATP4A (Potassium-transporting ATPase alpha chain 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.45, animal model 0.65, genetic association 0.00, clinical 0.91).
In plain words · ATP4A (Potassium-transporting ATPase alpha chain 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
ATP4A (Potassium-transporting ATPase alpha chain 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells.
No product in this corpus aims at ATP4A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ATP4A: RNA tissue enriched (stomach 1 780 nTPM); high antibody staining in 2 normal tissues. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (Zollinger-Ellison syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ATP4A tissue; Open Targets ENSG00000105675 associations
First described 1987. Earliest sequence paper UniProt cites for the protein: Sverdlov E.D. et al, FEBS Lett, 1987, "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". Source.
Sources: HGNC HGNC:819 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P20648 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105675 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: gastric cancer 0.56, non-Hodgkin lymphoma 0.52 (GraphQL API, CC0))
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state. Location: Apical cell membrane (UniProt). Locus 19q13.12 (HGNC).
RNA: tissue enriched (stomach 1 780 nTPM), detected in some normal tissues.
RNA cancer enriched: Stomach Adenocarcinoma 5 pTPM.
No cancer sample stained medium or high.
HPA ATP4A tissue · HPA ATP4A pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ATP4A" OR ABSTRACT:"ATP4A" OR TITLE:"ATPase H+/K+ transporting subunit alpha" OR ABSTRACT:"ATPase H+/K+ transporting subunit alpha" OR TITLE:"Potassium-transporting ATPase alpha chain 1" OR ABSTRACT:"Potassium-transporting ATPase alpha chain 1" OR TITLE:"ATP6A" OR ABSTRACT:"ATP6A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP4A, not a curated reading list.