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APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.97, animal model 0.50, genetic association 0.00).
In plain words · APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE.
No product in this corpus aims at APBB1IP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2003. Earliest sequence paper UniProt cites for the protein: Inagaki et al, J. Biol. Chem, 2003, "The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells". Source.
Sources: HGNC HGNC:17379 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z5R6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000077420 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Location: Cell membrane; Cell projection, lamellipodium; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10p12.1 (HGNC).
Query for this target: (TITLE:"APBB1IP" OR ABSTRACT:"APBB1IP" OR TITLE:"amyloid beta precursor protein binding family B member 1 interacting protein" OR ABSTRACT:"amyloid beta precursor protein binding family B member 1 interacting protein" OR TITLE:"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein" OR ABSTRACT:"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein" OR TITLE:"RARP1" OR ABSTRACT:"RARP1" OR TITLE:"PREL1" OR ABSTRACT:"PREL1" OR TITLE:"INAG1" OR ABSTRACT:"INAG1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APBB1IP, not a curated reading list.