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CDCA7 (Cell division cycle-associated protein 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.71).
In plain words · CDCA7 (Cell division cycle-associated protein 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
CDCA7 (Cell division cycle-associated protein 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells.
No product in this corpus aims at CDCA7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2001. Earliest sequence paper UniProt cites for the protein: Prescott J.E. et al, J. Biol. Chem, 2001, "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". Source.
Sources: HGNC HGNC:14628 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BWT1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000144354 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognises hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator. Location: Nucleus; Cytoplasm; Chromosome (UniProt). Locus 2q31.1 (HGNC).
Query for this target: (TITLE:"CDCA7" OR ABSTRACT:"CDCA7" OR TITLE:"cell division cycle associated 7" OR ABSTRACT:"cell division cycle associated 7" OR TITLE:"Cell division cycle-associated protein 7" OR ABSTRACT:"Cell division cycle-associated protein 7" OR TITLE:"FLJ14736" OR ABSTRACT:"FLJ14736" OR TITLE:"JPO1" OR ABSTRACT:"JPO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDCA7, not a curated reading list.