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EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.18, genetic association 0.61, genetic literature 0.61).
In plain words · EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton.
No product in this corpus aims at EHBP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:29144 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NDI1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115504 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.54 (GraphQL API, CC0))
May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. Location: Cytoplasm; Membrane; Endosome (UniProt). Locus 2p15 (HGNC).
Query for this target: (TITLE:"EHBP1" OR ABSTRACT:"EHBP1" OR TITLE:"EH domain binding protein 1" OR ABSTRACT:"EH domain binding protein 1" OR TITLE:"EH domain-binding protein 1" OR ABSTRACT:"EH domain-binding protein 1" OR TITLE:"KIAA0903" OR ABSTRACT:"KIAA0903" OR TITLE:"NACSIN" OR ABSTRACT:"NACSIN") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EHBP1, not a curated reading list.