{"entity":{"id":"ehbp1","kind":"target","name":"EHBP1","aka":["EH domain binding protein 1","EH domain-binding protein 1","KIAA0903","NACSIN"],"tldr":"EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.18, genetic association 0.61, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29144","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29144"},{"label":"UniProt Q8NDI1","url":"https://www.uniprot.org/uniprotkb/Q8NDI1/entry"},{"label":"NCBI Gene 23301","url":"https://www.ncbi.nlm.nih.gov/gene/23301"},{"label":"Ensembl ENSG00000115504","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115504"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EHBP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:29144","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29144","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NDI1","url":"https://www.uniprot.org/uniprotkb/Q8NDI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000115504","url":"https://platform.opentargets.org/target/ENSG00000115504/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.54 (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:29144","ensembl":"ENSG00000115504","uniprot":"Q8NDI1","entrez":"23301","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10048485/","biology":"May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. Location: Cytoplasm; Membrane; Endosome (UniProt). Locus 2p15 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/ehbp1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}