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TERT (Telomerase reverse transcriptase) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more.
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells.
CIViC holds 18 clinical evidence items and 0 assertions across 8 variants, naming UO126, Larotrectinib and Iodine I-131. Open Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.91, clinical 0.50, affected pathway 0.61, literature 1.00, genetic association 0.86, somatic mutation 0.90, animal model 0.27). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Papillary Renal Cell Carcinoma.
In plain words · TERT (Telomerase reverse transcriptase) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more.
TERT (Telomerase reverse transcriptase) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more.
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells.
No product in this corpus aims at TERT yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA TERT: RNA not detected; no normal tissue stained high. Distribution: 8 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Myeloid neoplasms, Leukaemia, Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), Bladder & urothelial cancer, Ovarian cancer and more); Open Targets associates it with 22 specific cancer types at or above 0.5 (dyskeratosis congenita, autosomal dominant 2, dyskeratosis congenita, acute myeloid leukemia, autosomal recessive dyskeratosis congenita 4, melanoma, cutaneous malignant, susceptibility to, 9, urinary bladder cancer and more). (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt O14746; CIViC gene TERT; IntOGen TERT; Human Protein Atlas TERT tissue; Open Targets ENSG00000164362 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Meyerson et al, Cell, 1997, "hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization". Source.
Sources: HGNC HGNC:11730 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14746 (protein name, function text, keywords and locations (REST API)); CIViC gene TERT (18 evidence items, 0 assertions, 8 variants; diseases: Glioblastoma, Thyroid Cancer, Brain Glioma, Papillary Thyroid Carcinoma, Clear Cell Renal Cell Carcinoma and 5 more (GraphQL API, CC0)); Open Targets ENSG00000164362 (association with cancer (MONDO_0004992) 0.86; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.60, colorectal cancer 0.61, gastric cancer 0.51, hepatocellular carcinoma 0.60, prostate cancer 0.61, urinary bladder cancer 0.64 (GraphQL API, CC0)); IntOGen TERT (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyses the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. Location: Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus; Chromosome, telomere (UniProt). Locus 5p15.33 (HGNC).
RNA: not detected, not detected normal tissues.
No normal tissue stained high.
No cancer stained high; medium in prostate cancer, thyroid cancer, urothelial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TERT" OR ABSTRACT:"TERT" OR TITLE:"telomerase reverse transcriptase" OR ABSTRACT:"telomerase reverse transcriptase" OR TITLE:"Telomerase reverse transcriptase" OR ABSTRACT:"Telomerase reverse transcriptase" OR TITLE:"TP2" OR ABSTRACT:"TP2" OR TITLE:"TCS1" OR ABSTRACT:"TCS1" OR TITLE:"hEST2" OR ABSTRACT:"hEST2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TERT, not a curated reading list.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), CIViC.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), CIViC.
Shares Leukaemia (all types), Skin cancer (all types), CIViC, IntOGen.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), CIViC.
Shares Leukaemia (all types), IntOGen, Ovarian cancer, Lung cancer (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Ovarian cancer.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Skin cancer (all types), Lung cancer (all types).