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ATP4B (Potassium-transporting ATPase subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2).
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.78, animal model 0.56, genetic association 0.00, clinical 0.91).
In plain words · ATP4B (Potassium-transporting ATPase subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
ATP4B (Potassium-transporting ATPase subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells.
No product in this corpus aims at ATP4B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ATP4B: RNA tissue enriched (stomach 1 1,002 nTPM); high antibody staining in 1 normal tissue. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (Zollinger-Ellison syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ATP4B tissue; Open Targets ENSG00000186009 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Ma J.-Y. et al, Biochem. Biophys. Res. Commun, 1991, "cDNA cloning of the beta-subunit of the human gastric H,K-ATPase". Source.
Sources: HGNC HGNC:820 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51164 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186009 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: gastric cancer 0.56, non-Hodgkin lymphoma 0.52 (GraphQL API, CC0))
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilising the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle. Location: Apical cell membrane; Cell membrane (UniProt). Locus 13q34 (HGNC).
RNA: tissue enriched (stomach 1 1,002 nTPM), detected in some normal tissues.
RNA cancer enriched: Stomach Adenocarcinoma 5 pTPM.
No cancer sample stained medium or high.
HPA ATP4B tissue · HPA ATP4B pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ATP4B" OR ABSTRACT:"ATP4B" OR TITLE:"ATPase H+/K+ transporting subunit beta" OR ABSTRACT:"ATPase H+/K+ transporting subunit beta" OR TITLE:"Potassium-transporting ATPase subunit beta" OR ABSTRACT:"Potassium-transporting ATPase subunit beta" OR TITLE:"ATP6B" OR ABSTRACT:"ATP6B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP4B, not a curated reading list.