{"entity":{"id":"atp4b","kind":"target","name":"ATP4B","aka":["ATPase H+/K+ transporting subunit beta","Potassium-transporting ATPase subunit beta","ATP6B"],"tldr":"ATP4B (Potassium-transporting ATPase subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Gastric & gastro-oesophageal junction cancer and Non-Hodgkin lymphoma.","summary":"The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2).\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.78, animal model 0.56, genetic association 0.00, clinical 0.91).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:820"},{"label":"UniProt P51164","url":"https://www.uniprot.org/uniprotkb/P51164/entry"},{"label":"NCBI Gene 496","url":"https://www.ncbi.nlm.nih.gov/gene/496"},{"label":"Ensembl ENSG00000186009","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186009"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["gastric","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.91. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ATP4B","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:820","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P51164","url":"https://www.uniprot.org/uniprotkb/P51164/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000186009","url":"https://platform.opentargets.org/target/ENSG00000186009/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: gastric cancer 0.56, non-Hodgkin lymphoma 0.52 (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ATP4B: RNA tissue enriched (stomach 1 1,002 nTPM); high antibody staining in 1 normal tissue. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer, Lymphoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (Zollinger-Ellison syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ATP4B tissue","url":"https://www.proteinatlas.org/ENSG00000186009-ATP4B/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000186009 associations","url":"https://platform.opentargets.org/target/ENSG00000186009/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:820","ensembl":"ENSG00000186009","uniprot":"P51164","entrez":"496","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ma J.-Y. et al, Biochem. Biophys. Res. Commun, 1991, \"cDNA cloning of the beta-subunit of the human gastric H,K-ATPase\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1656976/","biology":"The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilising the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle. Location: Apical cell membrane; Cell membrane (UniProt). Locus 13q34 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.56 with gastric cancer (MONDO_0001056)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)"],"targetClass":"other","prevalence":[]},"route":"/targets/atp4b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}