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AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.89, animal model 0.41, genetic association 0.00).
In plain words · AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
No product in this corpus aims at AGGF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Dickson M.C. et al, 1997. Source.
Sources: HGNC HGNC:24684 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8N302 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164252 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Location: Cytoplasm; Secreted (UniProt). Locus 5q13.3 (HGNC).
Query for this target: (TITLE:"AGGF1" OR ABSTRACT:"AGGF1" OR TITLE:"angiogenic factor with G-patch and FHA domains 1" OR ABSTRACT:"angiogenic factor with G-patch and FHA domains 1" OR TITLE:"Angiogenic factor with G patch and FHA domains 1" OR ABSTRACT:"Angiogenic factor with G patch and FHA domains 1" OR TITLE:"VG5Q" OR ABSTRACT:"VG5Q" OR TITLE:"HSU84971" OR ABSTRACT:"HSU84971" OR TITLE:"FLJ10283" OR ABSTRACT:"FLJ10283") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AGGF1, not a curated reading list.