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ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.73).
In plain words · ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.
No product in this corpus aims at ANO7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Bera T.K. et al, Proc. Natl. Acad. Sci. U.S.A, 2004, "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate". Source.
Sources: HGNC HGNC:31677 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6IWH7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000146205 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.57 (GraphQL API, CC0))
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. Location: Cell membrane; Cell junction; Endoplasmic reticulum; Cytoplasm, cytosol (UniProt). Locus 2q37.3 (HGNC).
Query for this target: (TITLE:"ANO7" OR ABSTRACT:"ANO7" OR TITLE:"anoctamin 7" OR ABSTRACT:"anoctamin 7" OR TITLE:"Anoctamin-7" OR ABSTRACT:"Anoctamin-7" OR TITLE:"PCANAP5L" OR ABSTRACT:"PCANAP5L" OR TITLE:"IPCA-5" OR ABSTRACT:"IPCA-5" OR TITLE:"PCANAP5" OR ABSTRACT:"PCANAP5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ANO7, not a curated reading list.