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ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.82, genetic association 0.67).
In plain words · ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA.
No product in this corpus aims at ARHGEF5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Chan A.M.-L. et al, Oncogene, 1994, "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Source.
Sources: HGNC HGNC:13209 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q12774 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000050327 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: breast cancer 0.50 (GraphQL API, CC0))
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organisation. Plays a role in actin organisation by generating a loss of actin stress fibres and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Location: Cytoplasm; Nucleus; Cell projection, podosome (UniProt). Locus 7q35 (HGNC).
Query for this target: (TITLE:"ARHGEF5" OR ABSTRACT:"ARHGEF5" OR TITLE:"Rho guanine nucleotide exchange factor 5" OR ABSTRACT:"Rho guanine nucleotide exchange factor 5" OR TITLE:"TIM1" OR ABSTRACT:"TIM1" OR TITLE:"GEF5" OR ABSTRACT:"GEF5" OR TITLE:"P60" OR ABSTRACT:"P60") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGEF5, not a curated reading list.