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ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organisation. Plays a role in actin organisation by generating a loss of actin stress fibres and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Location: Cytoplasm; Nucleus; Cell projection, podosome (UniProt). Locus 7q35 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ARHGEF5" OR ABSTRACT:"ARHGEF5" OR TITLE:"Rho guanine nucleotide exchange factor 5" OR ABSTRACT:"Rho guanine nucleotide exchange factor 5" OR TITLE:"TIM1" OR ABSTRACT:"TIM1" OR TITLE:"GEF5" OR ABSTRACT:"GEF5" OR TITLE:"P60" OR ABSTRACT:"P60") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGEF5, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/arhgef5.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/arhgef5.json. Licence CC BY-NC 4.0.