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ADAM29 (Disintegrin and metalloproteinase domain-containing protein 29) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
May be involved in spermatogenesis and fertilisation. Seems to be a non catalytic metalloprotease-like protein.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.65).
In plain words · ADAM29 (Disintegrin and metalloproteinase domain-containing protein 29) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
ADAM29 (Disintegrin and metalloproteinase domain-containing protein 29) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
May be involved in spermatogenesis and fertilisation. Seems to be a non catalytic metalloprotease-like protein.
No product in this corpus aims at ADAM29 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Cerretti D.P. et al, Biochem. Biophys. Res. Commun, 1999, "Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression". Source.
Sources: HGNC HGNC:207 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UKF5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168594 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0))
May be involved in spermatogenesis and fertilisation. Seems to be a non catalytic metalloprotease-like protein. Location: Membrane (UniProt). Locus 4q34.1 (HGNC).
Query for this target: (TITLE:"ADAM29" OR ABSTRACT:"ADAM29" OR TITLE:"ADAM metallopeptidase domain 29" OR ABSTRACT:"ADAM metallopeptidase domain 29" OR TITLE:"Disintegrin and metalloproteinase domain-containing protein 29" OR ABSTRACT:"Disintegrin and metalloproteinase domain-containing protein 29" OR TITLE:"svph1" OR ABSTRACT:"svph1" OR TITLE:"CT73" OR ABSTRACT:"CT73") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADAM29, not a curated reading list.