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AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.19, genetic association 0.00, somatic mutation 0.23, animal model 0.48).
In plain words · AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes.
No product in this corpus aims at AP3B1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Simpson et al, J. Cell Biol, 1997, "Characterization of the adaptor-related protein complex, AP-3". Source.
Sources: HGNC HGNC:566 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00203 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132842 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Location: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Golgi apparatus (UniProt). Locus 5q14.1 (HGNC).
Query for this target: (TITLE:"AP3B1" OR ABSTRACT:"AP3B1" OR TITLE:"adaptor related protein complex 3 subunit beta 1" OR ABSTRACT:"adaptor related protein complex 3 subunit beta 1" OR TITLE:"AP-3 complex subunit beta-1" OR ABSTRACT:"AP-3 complex subunit beta-1" OR TITLE:"ADTB3A" OR ABSTRACT:"ADTB3A" OR TITLE:"HPS2" OR ABSTRACT:"HPS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AP3B1, not a curated reading list.