Loading
CHRNA5 (Neuronal acetylcholine receptor subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitisation kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.65, somatic mutation 0.26).
In plain words · CHRNA5 (Neuronal acetylcholine receptor subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
CHRNA5 (Neuronal acetylcholine receptor subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities.
No product in this corpus aims at CHRNA5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1992. Earliest sequence paper UniProt cites for the protein: Chini et al, Proc. Natl. Acad. Sci. U.S.A, 1992, "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines". Source.
Sources: HGNC HGNC:1959 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30532 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169684 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: lung cancer 0.53 (GraphQL API, CC0))
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitisation kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction. Location: Synaptic cell membrane; Cell membrane (UniProt). Locus 15q25.1 (HGNC).
Query for this target: (TITLE:"CHRNA5" OR ABSTRACT:"CHRNA5" OR TITLE:"cholinergic receptor nicotinic alpha 5 subunit" OR ABSTRACT:"cholinergic receptor nicotinic alpha 5 subunit" OR TITLE:"Neuronal acetylcholine receptor subunit alpha-5" OR ABSTRACT:"Neuronal acetylcholine receptor subunit alpha-5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CHRNA5, not a curated reading list.