Loading
BCL3 (B-cell lymphoma 3 protein) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, animal model 0.53, genetic association 0.00, somatic mutation 0.95).
In plain words · BCL3 (B-cell lymphoma 3 protein) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
BCL3 (B-cell lymphoma 3 protein) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit.
No product in this corpus aims at BCL3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1990. Earliest sequence paper UniProt cites for the protein: Ohno et al, Cell, 1990, "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Source.
Sources: HGNC HGNC:998 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P20749 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000069399 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.54 (GraphQL API, CC0))
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. Location: Nucleus; Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 19q13.32 (HGNC).
Query for this target: (TITLE:"BCL3" OR ABSTRACT:"BCL3" OR TITLE:"BCL3 transcription coactivator" OR ABSTRACT:"BCL3 transcription coactivator" OR TITLE:"B-cell lymphoma 3 protein" OR ABSTRACT:"B-cell lymphoma 3 protein" OR TITLE:"D19S37" OR ABSTRACT:"D19S37" OR TITLE:"BCL4" OR ABSTRACT:"BCL4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCL3, not a curated reading list.