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Most lab experiments that fail are never written up, so other labs repeat them. A simple, structured registry with a citable record for each failed experiment would stop the waste.
Negative preclinical findings (a drug that did not work in a model, a target that did not validate, a biomarker that did not predict) have no home. A registry with minimal structured fields (target, model, intervention, readout, result, methods link, raw data), each with a DOI, and integrated into the major databases, would make failures findable. Funders would require deposit for supported projects.
Shares Living systematic reviews of animal and organoid evidence before every new trial, Compliance with results reporting at ClinicalTrials.gov, Failures are hidden.
Shares A target de-risking index that counts failures as well as successes, Compliance with results reporting at ClinicalTrials.gov, Failures are hidden.
Shares Compliance with results reporting at ClinicalTrials.gov, Preclinical results do not reproduce, Failures are hidden.
Shares Bounties for documented failed replications of high-impact findings, Preclinical results do not reproduce, PubMed & Europe PMC.
Shares A funder-backed, indexed journal of negative and inconclusive cancer results, Preclinical results do not reproduce, Failures are hidden.
Shares Preclinical results do not reproduce, Failures are hidden, PubMed & Europe PMC.
Shares Bounties for documented failed replications of high-impact findings, Preclinical results do not reproduce.
Shares Compliance with results reporting at ClinicalTrials.gov, Failures are hidden.