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Pay a fixed reward to any lab that pre-registers and carefully repeats a heavily cited preclinical cancer finding, whatever the outcome, with a bonus for the first documented non-replication that passes methodological review. Today that work is unpaid and unpublished.
Security research uses bug bounties to reward finding flaws. A replication bounty programme would list high-impact preclinical oncology findings (selected by citations and translational stage), pay a fixed sum for a pre-registered, adequately powered replication attempt regardless of outcome, and a bonus for the first documented non-replication that passes methodological review. Results are published in a registry.
Shares A replication status badge on every cancer paper, visible in PubMed, Funders set aside a fixed share of budget for independent replication, Preclinical results do not reproduce.
Shares A registry for preclinical experiments that did not work, Preclinical results do not reproduce, Failures are hidden.
Shares A replication status badge on every cancer paper, visible in PubMed, Preclinical results do not reproduce, Failures are hidden.
Shares Funders set aside a fixed share of budget for independent replication, Preclinical results do not reproduce.
Shares A registry for preclinical experiments that did not work, Failures are hidden.
Shares A registry for preclinical experiments that did not work, Failures are hidden.
Shares A registry for preclinical experiments that did not work, Failures are hidden.
Shares Preclinical results do not reproduce, Failures are hidden.