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Before testing a drug in people, someone should systematically gather all the animal and laboratory evidence, including the studies that failed. Almost no cancer trial does this.
CAMARADES and the SYRCLE group have shown that systematic review and meta-analysis of preclinical studies reveals publication bias, small-study effects and true effect sizes far below those in the headline papers. Requiring a registered, continuously updated systematic review of preclinical evidence (with automated literature surveillance) as part of any trial protocol or ethics application would ground trial decisions in the whole evidence base.
Shares A registry for preclinical experiments that did not work, Preclinical results do not reproduce, Failures are hidden.
Shares A registry for preclinical experiments that did not work, Failures are hidden.
Shares A registry for preclinical experiments that did not work, Failures are hidden.
Shares Preclinical results do not reproduce, Failures are hidden.
Shares A registry for preclinical experiments that did not work, Failures are hidden.
Shares Preclinical results do not reproduce, Failures are hidden.
Shares Preclinical results do not reproduce, Failures are hidden.
Shares Preclinical results do not reproduce, Failures are hidden.