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Ideas
Alert guidelines and trials when a paper they rely on is retracted

Alert guidelines and trials when a paper they rely on is retracted

When a study is retracted, everything built on it should get a warning. Today, retracted cancer papers keep being cited and used for years.

Overview Connected6

Overview

Retracted papers continue to be cited, and guidelines or trial protocols that relied on them are rarely revisited. A service that maps retractions and expressions of concern (from Retraction Watch and publishers) onto the citation graph and notifies guideline bodies, trial registries and systematic reviews that cite the retracted work would close a loop that is currently open.

Hypothesis

Within a year of launch, at least 80% of oncology guidelines citing a retracted paper have been notified and at least half have issued an update or statement.

Rationale

Retraction Watch's database now makes retractions machine-readable; citation graphs from OpenAlex make propagation computable. The missing piece is delivery to the people who act on the evidence.

Proposed test

Run the service over oncology guidelines from three societies; count notifications and responses.

Maturity

speculative

Who acts

data

Cost to try

Small (under $1M)

Years to first evidence

1

Bottlenecks it attacks

Failures are hidden · Negative trials, failed drugs and abandoned programmes are rarely published, so the same mistakes are repeated.
Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.

Connected

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ideas

A replication status badge on every cancer paper, visible in PubMed

collections

ESMO Clinical Practice Guidelines & MCBS NCCN Guidelines PubMed & Europe PMC

bottlenecks

Failures are hidden Preclinical results do not reproduce

ProvenanceLast edited 2026-09-08 · Jude Gomila · Ideas wave · diff · file

Sources & links

Retraction Watch Database

Data

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Propose a change with a source. Organisations can update their own records. Every suggestion is reviewed, safety-checked and validated before it goes live; nothing is edited directly.

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Out of date?
How review works

Related

ESMO Clinical Practice Guidelines & MCBS
NCCN Guidelines
PubMed & Europe PMC

Not yet reviewedNeeds expert (scientific) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Machine-readable versions of Alert guidelines and trials when a paper they rely on is retracted

JSON record with neighbours
Markdown context for language models
RDF Turtle for this record (its triples, relations and owl:sameAs; the IRI of this record is https://onco.cc/ideas/idea-tr2-retraction-propagation/)
All ideas as JSON
RDF N-Triples for the whole corpus
Search index: id, kind, name, TL;DR and route for every record
OpenAPI 3.1 description
API root and meta.json
llms.txt

MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id idea-tr2-retraction-propagation.

WebMCP tools registered on this page: onco_search, onco_get_entity.