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NCCN Guidelines
The algorithms US oncologists follow. If a drug is in NCCN, insurers usually pay.
Overview
The NCCN Guidelines are US clinical practice guidelines for every cancer type, updated continuously by the National Comprehensive Cancer Network, an alliance of 33 US centres. They are the algorithms US oncologists follow, each option carries a category of evidence and a preference ranking, and patient versions are also published; if a drug appears in NCCN, US insurers usually pay for it. Access is free with registration for non-commercial use. On OnCo the guidelines are linked to the term Standard of care and the institution National Comprehensive Cancer Network (NCCN), and they are cited by the bottlenecks Prices and value, Fragmented care and guideline gaps, Knowledge reaches practice too slowly and Misinformation and unproven therapies, among others.
Holds
US clinical practice guidelines for every cancer type, updated continuously.
Licence
Free with registration (non-commercial)
Maintainer
National Comprehensive Cancer Network (33 US centres)
guidelineJournal of the National Comprehensive Cancer Network 2026changed practice0 citations
Breast Cancer, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology
NCCN is the source of the category grades on the triple-negative breast cancer page and the first major guideline to place an antibody-drug conjugate first line for the disease.
guidelineJournal of the National Comprehensive Cancer Network 2025changed practice64 citations
Biliary Tract Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology
NCCN is the source of the category grades quoted on the gallbladder cancer page; the adjuvant section leans on BILCAP for capecitabine and on SWOG S0809 for chemoradiation after margin-positive or node-positive resection.
guidelineJournal of the National Comprehensive Cancer Network 2021changed practice983 citations
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
NCCN is the source of the category grades on the pancreatic cancer page and the guideline that first placed germline testing for every patient and universal tumour profiling in routine care.
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institutions
terms
roadmaps
ideas
A cheap old tablet to restore appetiteA fixed share of trial-group funding for getting proven care to patientsA guideline fast track for repurposed drugs with phase 3 evidence but no manufacturerAlert guidelines and trials when a paper they rely on is retractedChoose regimens by infusion-chair hours, not just efficacy, where chairs are the constraintGuidelines list the open trials at every decision point, updated monthlyLabel every biomarker claim with an evidence phase, like drugsLive guideline-concordance dashboards for every tumour board, generated from the recordLiving guidelines published as versioned, computable rulesOffline decision support for generalists treating common cancers in low-resource settingsOpen licences for publicly funded cancer guidelines