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A low dose of an old, inexpensive tablet improved appetite and weight in a randomised trial of people with advanced cancer. It could be used almost everywhere tomorrow.
Low-dose olanzapine, at 2.5 mg daily, improved appetite, weight gain and quality of life versus placebo in a randomised trial in patients with advanced gastrointestinal and lung cancer receiving chemotherapy, conducted at Tata Memorial. The drug is generic, oral, off-patent and already used for chemotherapy-induced nausea, so implementation requires guideline change rather than development.
Shares Low-dose olanzapine for cancer anorexia (Tata Memorial), Cachexia, toxicity and the limits of the patient, Tata Memorial Centre, No incentive to repurpose cheap drugs.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cachexia, toxicity and the limits of the patient, Most of the world has almost no cancer care.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cachexia, toxicity and the limits of the patient, Gastric & gastro-oesophageal junction cancer.
Shares NCCN Guidelines, ESMO Clinical Practice Guidelines & MCBS, No incentive to repurpose cheap drugs.
Shares Low-dose olanzapine for cancer anorexia (Tata Memorial), Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Non-small-cell lung cancer.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Colorectal cancer, Non-small-cell lung cancer.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Non-small-cell lung cancer.