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The wasting that kills many cancer patients has had no effective drug. New antibodies against GDF-15 restored weight in early trials. Combine them with exercise and nutrition and test properly.
Cancer cachexia affects a large share of patients with pancreatic, lung and gastric cancer and contributes directly to death and treatment intolerance. Ponsegromab, an anti-GDF-15 antibody, increased weight and activity in a randomised phase 2 trial; ghrelin agonists (anamorelin) are approved in Japan. The proposal is a programme treating cachexia as an indication in its own right: standardised diagnosis and staging, a phase 3 of GDF-15 blockade with function and survival endpoints, and multimodal bundles combining pharmacotherapy with resistance exercise and nutritional support, embedded early in oncology care rather than at end of life.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology, Toxicity and quality of life are undervalued.
Shares Resistance training and protein for cachexia and sarcopenia, Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology, Pfizer (incl. Seagen).
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Pfizer (incl. Seagen).
Shares Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cachexia, toxicity and the limits of the patient, Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Exercise & lifestyle oncology.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology, Non-small-cell lung cancer.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cachexia, toxicity and the limits of the patient, Gastric & gastro-oesophageal junction cancer.
Shares Resistance training and protein for cachexia and sarcopenia, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Exercise & lifestyle oncology.