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Structured exercise during and after treatment, which the CHALLENGE trial showed improves survival in colon cancer.
The CHALLENGE trial (NEJM 2025) randomised colon cancer survivors to a structured exercise programme and showed improved disease-free and overall survival, the first level-1 evidence that exercise changes cancer outcomes. Exercise also reduces fatigue, cardiotoxicity, and chemotherapy-induced neuropathy.
Aerobic and resistance training modulate insulin, inflammation, and immune function.
Query for this technology: (TITLE:"exercise oncology" OR ABSTRACT:"exercise oncology" OR TITLE:"exercise intervention" OR ABSTRACT:"exercise intervention") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma) AND survival. Results are unfiltered search hits about Exercise & lifestyle oncology, not a curated reading list.
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