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A new antibody blocks the hormone that makes people with cancer lose appetite and weight. Weight regained as muscle, not fat, needs exercise and protein alongside it.
GDF-15 is a tumour-derived hormone acting on the brainstem GFRAL receptor to suppress appetite, and a randomised phase 2 of the anti-GDF-15 antibody ponsegromab reported weight gain and improved appetite in cancer cachexia. Weight gain alone is not the goal: without a resistance training and protein stimulus, regained mass is likely to be fat rather than functional muscle.
Shares Resistance training and protein for cachexia and sarcopenia, Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology, Pfizer (incl. Seagen).
Shares Ponsegromab phase 2 in cancer cachexia, Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds, Resistance training and protein for cachexia and sarcopenia, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment.
Shares CHALLENGE: a structured exercise programme after chemotherapy improves survival in colon cancer, Structured exercise prescribed like a drug in all curative-intent cancer care, Cachexia, toxicity and the limits of the patient, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment.
Shares Ponsegromab phase 2 in cancer cachexia, Cachexia, toxicity and the limits of the patient, Pfizer (incl. Seagen), Pancreatic ductal adenocarcinoma.
Shares Ponsegromab phase 2 in cancer cachexia, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Exercise & lifestyle oncology, Pancreatic ductal adenocarcinoma.
Shares Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology, Toxicity and quality of life are undervalued, Pancreatic ductal adenocarcinoma.
Shares Ponsegromab phase 2 in cancer cachexia, Cachexia, toxicity and the limits of the patient, Pancreatic ductal adenocarcinoma, Non-small-cell lung cancer.
Shares Structured exercise prescribed like a drug in all curative-intent cancer care, Cachexia, toxicity and the limits of the patient, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Exercise & lifestyle oncology.