Loading
Lifting weights and eating enough protein is the only treatment shown to build muscle in people with cancer wasting, but most are too unwell to do it alone and the trials are small.
Skeletal muscle in cachexia remains anabolically responsive if enough protein (1.2-1.5 g/kg/day, ESPEN 2021) and mechanical loading are provided. Small randomised trials and the multimodal MENAC feasibility trial (exercise, nutrition, NSAID) show preserved or increased lean mass and function, but no adequately powered trial has yet shown that exercise prolongs survival or reverses established refractory cachexia. Adherence is the constraint: the patients who most need it are the least able to attend. Combination with appetite or anti-GDF-15 drugs is the rational next step and is being planned.
Progressive resistance exercise activates mTOR-dependent muscle protein synthesis and blunts the ubiquitin-proteasome degradation driven by inflammatory cytokines; protein and leucine supply the substrate.
Three technology pages and two term pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Resistance training and protein for cachexia and sarcopenia" OR ABSTRACT:"Resistance training and protein for cachexia and sarcopenia") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Resistance training and protein for cachexia and sarcopenia, not a curated reading list.
Shares Combine the new anti-wasting antibody with exercise and protein, Cachexia-directed therapy (GDF-15 blockade), Cancer cachexia, Body composition (lean mass, fat mass, visceral fat).
Shares ESPEN practical guideline: Clinical Nutrition in cancer, Fish oil (EPA) for cancer weight loss, Body composition (lean mass, fat mass, visceral fat), Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds.
Shares Cachexia-directed therapy (GDF-15 blockade), Cancer cachexia, Body composition (lean mass, fat mass, visceral fat), Sarcopenia.
Shares Measuring muscle and fat on scans the patient already had, Body composition (lean mass, fat mass, visceral fat), Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds, Sarcopenia.
Shares ESPEN practical guideline: Clinical Nutrition in cancer, Sarcopenia, Cancer cachexia, Nutrition support and cachexia management.
Shares Body composition (lean mass, fat mass, visceral fat), Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds, Sarcopenia, Cachexia, toxicity and the limits of the patient.
Shares Cancer cachexia, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Exercise & lifestyle oncology, Gastric & gastro-oesophageal junction cancer.
Shares Measuring muscle and fat on scans the patient already had, Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds, Sarcopenia, The exercise prescription after cancer: the dose the guidelines state.