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Sarcopenia is loss of muscle mass and strength. In cancer it predicts worse chemotherapy side-effects, more surgical complications and shorter survival, and it can hide in people who look a normal weight or overweight.
Defined by low skeletal muscle mass (commonly the skeletal muscle index at the L3 vertebra on CT) with or without low strength or performance. Sarcopenic obesity, low muscle with high fat, carries the worst prognosis. Because muscle rather than total weight determines the clearance of many cytotoxics, sarcopenic patients dosed by body surface area are effectively overdosed. Automated CT segmentation makes opportunistic measurement feasible.
Showing the technology this term belongs to: Resistance training and protein for cachexia and sarcopenia.
Shares Fish oil (EPA) for cancer weight loss, ROMANA 1 and ROMANA 2, Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds, Resistance training and protein for cachexia and sarcopenia.
Shares Fish oil (EPA) for cancer weight loss, Pancreatic enzyme replacement therapy (PERT, pancreatin, Creon) for pancreatic exocrine insufficiency: why and how to take it, Measuring muscle and fat on scans the patient already had, Malnutrition screening tools (MUST, NRS-2002, MST, PG-SGA).
Shares ROMANA 1 and ROMANA 2, Resistance training and protein for cachexia and sarcopenia, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cancer cachexia.
Shares Pancreatic enzyme replacement therapy (PERT, pancreatin, Creon) for pancreatic exocrine insufficiency: why and how to take it, Malnutrition screening tools (MUST, NRS-2002, MST, PG-SGA), Oncology nutrition assessment and medical nutrition therapy, Cancer cachexia.
Shares Malnutrition screening tools (MUST, NRS-2002, MST, PG-SGA), Oncology nutrition assessment and medical nutrition therapy, Cancer cachexia, Cachexia, toxicity and the limits of the patient.
Shares Body composition (lean mass, fat mass, visceral fat), Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cancer cachexia, Cachexia, toxicity and the limits of the patient.
Shares ROMANA 1 and ROMANA 2, Cachexia pharmacotherapy: GDF-15 blockade, anamorelin, olanzapine, Cachexia, toxicity and the limits of the patient, Geriatric assessment.
Shares Exercise is the best-evidenced thing on this front, and most survivors are not doing it, Referral to rehabilitation: the service most people who need it never see, Muscle and strength after treatment: sarcopenia, cachexia and what rebuilds, What the randomised trials of prehabilitation found, operation by operation.