Screening for malnutrition, dietitian-led counselling, supplements and tube or intravenous feeding where indicated, plus treatment of cancer cachexia, the muscle-wasting syndrome that affects up to 80% of advanced patients.
Malnutrition affects 20-70% of patients depending on tumour and stage and is an independent predictor of mortality, toxicity and complications. ESPEN (2017, 2021) and ASCO (2020) guidelines recommend routine screening (NRS-2002, PG-SGA), dietitian counselling, oral supplements, enteral feeding for head and neck and oesophageal cancer during chemoradiation, and limited use of parenteral nutrition. Cachexia (weight loss >5% with sarcopenia and inflammation, Fearon 2011 consensus) has its first approved drug in Japan (anamorelin, ghrelin agonist, 2021; EMA refused 2017); ponsegromab (anti-GDF-15) increased weight in a phase 2 trial (NEJM 2024) and is in phase 3. Exercise and protein intake are the non-pharmacologic core; immunonutrition before surgery reduces infections.
Screen at diagnosis and during treatment; intervene in stepwise fashion from counselling to artificial nutrition; treat cachexia as a multimodal problem (nutrition, exercise, anti-inflammatory/appetite drugs) rather than by feeding alone.
Enzyme capsules taken with every meal replace the digestive enzymes a pancreas blocked or removed by cancer no longer delivers; NICE says to offer them to everyone with unresectable pancreatic cancer and to consider them around surgery.
Query for this technology: (TITLE:"Nutrition support and cachexia management" OR ABSTRACT:"Nutrition support and cachexia management") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Nutrition support and cachexia management, not a curated reading list.
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