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Injections of filgrastim or its long-acting form pegfilgrastim after chemotherapy make white cells recover faster, cutting the risk of life-threatening infections and allowing chemotherapy on schedule.
Filgrastim (1991) and pegfilgrastim (2002) reduce febrile neutropenia incidence by ~50% and infection-related mortality; guidelines (ASCO, EORTC, NCCN) recommend primary prophylaxis when regimen risk of febrile neutropenia is >20% or 10-20% with patient risk factors, and secondary prophylaxis after an episode. Biosimilars (since 2015 in the US) cut cost; on-body injectors and same-day dosing trials address logistics. Efbemalenograstim and eflapegrastim (2022) are newer long-acting forms; trilaciclib (CDK4/6 inhibitor, 2021) protects marrow in SCLC; plinabulin failed. Febrile neutropenia itself is managed by risk score (MASCC, CISNE) with outpatient oral antibiotics for low risk. G-CSF also mobilises stem cells (with plerixafor) and is contraindicated during concurrent chemoradiation to the chest.
Recombinant granulocyte colony-stimulating factor accelerates neutrophil precursor proliferation and release, shortening the neutropenic nadir after myelosuppressive chemotherapy.
Efbemalenograstim alfa (Ryzneuta) is a once-per-cycle white cell booster, an alternative to pegfilgrastim, that reduces the risk of febrile infections after chemotherapy.
Filgrastim (Neupogen and its biosimilars) is a daily injection that speeds the recovery of infection-fighting white cells after chemotherapy, lets doctors give chemotherapy on schedule and mobilises stem cells for transplant.
Lipegfilgrastim (Lonquex) is a once-per-chemotherapy-cycle white cell booster used in Europe, similar to pegfilgrastim, for adults and children from two years old.
Pegfilgrastim (Neulasta) is a long-acting form of the growth factor G-CSF, given once per chemotherapy cycle to speed white cell recovery and prevent febrile neutropenia; one dose replaces about eleven daily filgrastim injections. Biosimilars have been sold since 2018 and the Onpro on-body injector delivers it automatically the day after chemotherapy; bone pain is the main side effect.
Query for this technology: (TITLE:"Growth factors: G-CSF and febrile neutropenia prevention" OR ABSTRACT:"Growth factors: G-CSF and febrile neutropenia prevention") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Growth factors: G-CSF and febrile neutropenia prevention, not a curated reading list.
Shares Filgrastim (G-CSF), Autologous stem cell transplant (high-dose therapy), Diffuse large B-cell lymphoma and the tag supportive.
Shares Lower-risk myelodysplastic syndromes, Transfusion support and anaemia management and the tag supportive.
Shares Lower-risk myelodysplastic syndromes, Transfusion support and anaemia management and the tag supportive.
Shares Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Advanced-stage classical Hodgkin lymphoma (stage III to IV), Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Diffuse large B-cell lymphoma and the tag supportive.
Shares Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs and the tag supportive.
Shares Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Advanced-stage classical Hodgkin lymphoma (stage III to IV), Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Diffuse large B-cell lymphoma and the tag supportive.
Shares Autologous stem cell transplant (high-dose therapy), Diffuse large B-cell lymphoma and the tag supportive.
Shares Supportive care and survivorship roadmap: making treatment bearable → proving it extends life → caring for tens of millions afterwards, Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs and the tag supportive.