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Palifermin (Kepivance) is a growth factor injected for three days before and after high-dose chemotherapy and stem cell rescue to reduce the severe mouth ulcers (mucositis) that this treatment causes in people with blood cancers.
Palifermin was approved by the FDA in December 2004 to decrease the incidence and duration of severe oral mucositis in patients with haematological malignancies receiving myelotoxic therapy with autologous stem cell support, when the regimen is expected to cause WHO grade 3 or worse mucositis in most patients; in the pivotal randomised trial of 212 patients receiving total body irradiation-based conditioning, grade 3 to 4 mucositis fell from 98% to 63% and its duration from 9 to 3 days. The EU authorised Kepivance in 2005. Its safety in non-haematological malignancies is not established because KGF receptors are present on many epithelial tumours, and it is not given within 24 hours of chemotherapy. Rash, tongue thickening and taste change are the usual effects. Marketed by Sobi.
Truncated recombinant KGF (FGF7) that binds the KGF receptor (FGFR2b) on epithelial cells of the mouth and gut, stimulating proliferation, differentiation and cytoprotection of the mucosa.
1.Palifermin slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 2004 | Reduction of severe oral mucositis in haematological malignancies with myelotoxic therapy and autologous stem cell support |
| EU | 2005 | Same (Kepivance) |
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Query for this drug: (TITLE:"Palifermin" OR ABSTRACT:"Palifermin" OR TITLE:"Kepivance" OR ABSTRACT:"Kepivance" OR TITLE:"Recombinant keratinocyte growth factor" OR ABSTRACT:"Recombinant keratinocyte growth factor" OR TITLE:"rHuKGF" OR ABSTRACT:"rHuKGF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Palifermin, not a curated reading list.
Shares Autologous stem cell transplant (high-dose therapy), Multiple myeloma, Diffuse large B-cell lymphoma and the tag supportive.
Shares Autologous stem cell transplant (high-dose therapy) and the tag supportive.
Shares Autologous stem cell transplant (high-dose therapy), Diffuse large B-cell lymphoma and the tag supportive.
Shares Multiple myeloma, Diffuse large B-cell lymphoma and the tag supportive.
Shares Diffuse large B-cell lymphoma and the tag supportive.
Shares Multiple myeloma and the tag supportive.
Shares Hodgkin lymphoma, Diffuse large B-cell lymphoma and the tag supportive.
Shares Hodgkin lymphoma, Diffuse large B-cell lymphoma and the tag supportive.