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FGF7 (Fibroblast growth factor 7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, animal model 0.55, genetic association 0.45). In OnCo, 1 product record names it (Palifermin).
In plain words · FGF7 (Fibroblast growth factor 7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
FGF7 (Fibroblast growth factor 7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis.
No product in this corpus aims at FGF7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Palifermin) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA FGF7: RNA low tissue specificity; no normal tissue stained high; highest cancer staining thyroid cancer (1 of 4 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (female reproductive endometrioid cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas FGF7 tissue; Open Targets ENSG00000140285 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Finch P.W. et al, Science, 1989, "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Source.
Sources: HGNC HGNC:3685 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P21781 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140285 (association with cancer (MONDO_0004992) 0.69; (GraphQL API, CC0))
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Location: Secreted (UniProt). Locus 15q21.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Kidney Chromophobe 35 pTPM.
Medium only: endometrial cancer, head and neck cancer, lung cancer, melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FGF7" OR ABSTRACT:"FGF7" OR TITLE:"fibroblast growth factor 7" OR ABSTRACT:"fibroblast growth factor 7" OR TITLE:"Fibroblast growth factor 7" OR ABSTRACT:"Fibroblast growth factor 7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF7, not a curated reading list.