{"entity":{"id":"fgf7","kind":"target","name":"FGF7","aka":["fibroblast growth factor 7","Fibroblast growth factor 7"],"tldr":"FGF7 (Fibroblast growth factor 7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, animal model 0.55, genetic association 0.45). In OnCo, 1 product record names it (Palifermin).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3685","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3685"},{"label":"UniProt P21781","url":"https://www.uniprot.org/uniprotkb/P21781/entry"},{"label":"NCBI Gene 2252","url":"https://www.ncbi.nlm.nih.gov/gene/2252"},{"label":"Ensembl ENSG00000140285","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140285"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["palifermin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FGF7","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:3685","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3685","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P21781","url":"https://www.uniprot.org/uniprotkb/P21781/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140285","url":"https://platform.opentargets.org/target/ENSG00000140285/associations","note":"association with cancer (MONDO_0004992) 0.69;  (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; the 1 medicine aimed at it (Palifermin) act on the wild-type protein, so normal tissue is exposed and the therapeutic window comes from the tumour's faster division or its dependence on the protein. HPA FGF7: RNA low tissue specificity; no normal tissue stained high; highest cancer staining thyroid cancer (1 of 4 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (female reproductive endometrioid cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas FGF7 tissue","url":"https://www.proteinatlas.org/ENSG00000140285-FGF7/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000140285 associations","url":"https://platform.opentargets.org/target/ENSG00000140285/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3685","ensembl":"ENSG00000140285","uniprot":"P21781","entrez":"2252","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Finch P.W. et al, Science, 1989, \"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2475908/","biology":"Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Location: Secreted (UniProt). Locus 15q21.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fgf7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"drug":[{"id":"palifermin","kind":"drug","name":"Palifermin","route":"/drugs/palifermin/"}]}}