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Plerixafor (Mozobil) is an injection given with G-CSF to flush stem cells out of the bone marrow into the blood so that enough can be collected for an autologous transplant in myeloma or lymphoma.
Plerixafor was approved by the FDA in December 2008 in combination with filgrastim to mobilise haematopoietic stem cells for collection and autologous transplantation in non-Hodgkin lymphoma and multiple myeloma, on two placebo-controlled phase 3 trials in which the proportion of patients reaching the target cell dose in few apheresis sessions roughly doubled; the EU authorised Mozobil in 2009 and a paediatric extension followed. It is used routinely for poor mobilisers and increasingly pre-emptively, and the same CXCR4 blockade underlies its investigation to mobilise stem cells for gene therapy and to sensitise leukaemia to chemotherapy. Motixafortide (Aphexda, 2023) is a longer-acting CXCR4 antagonist for the same purpose. Diarrhoea, nausea and injection-site reactions are common.
Bicyclam that reversibly blocks CXCR4 binding of stromal-derived factor-1 (CXCL12), releasing haematopoietic stem cells from bone marrow niches into the blood within hours. Connects to CXCR4.
1.Plerixafor slips into a pocket on CXCR4.
Compare all products across the US, EU, UK, Japan, China and Australia →
| Region | Year | Indication |
|---|---|---|
| US | 2008 | Stem cell mobilisation with filgrastim for autologous transplantation in NHL and multiple myeloma |
| EU | 2009 | Stem cell mobilisation with G-CSF in lymphoma and multiple myeloma with poor mobilisation (Mozobil) |
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Query for this drug: (TITLE:"Plerixafor" OR ABSTRACT:"Plerixafor" OR TITLE:"Mozobil" OR ABSTRACT:"Mozobil" OR TITLE:"AMD3100" OR ABSTRACT:"AMD3100") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Plerixafor, not a curated reading list.
Shares Autologous stem cell transplant (high-dose therapy), Multiple myeloma, Diffuse large B-cell lymphoma and the tag supportive.
Shares Filgrastim (G-CSF), Autologous stem cell transplant (high-dose therapy), Diffuse large B-cell lymphoma and the tag supportive.
Shares Sanofi, Diffuse large B-cell lymphoma and the tag supportive.
Shares Filgrastim (G-CSF) and the tag supportive.
Shares Autologous stem cell transplant (high-dose therapy) and the tag supportive.
Shares Sanofi and the tag supportive.
Shares Mantle cell lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and the tag supportive.
Shares Mantle cell lymphoma, Follicular lymphoma, Diffuse large B-cell lymphoma and the tag supportive.