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Apheresis is collecting a patient's white blood cells through a machine over several hours. Every autologous CAR-T begins here, and the quality of these cells shapes the final product.
Leukapheresis on Terumo BCT Spectra Optia or Fresenius Kabi Amicus/LOVO devices collects mononuclear cells at qualified centres; T-cell fitness at collection (affected by prior chemotherapy, bendamustine, and disease burden) predicts CAR-T expansion and response. Slot availability at apheresis units is a hidden bottleneck for CAR-T access, and standardisation of collection protocols is part of every sponsor's site qualification.
Continuous-flow centrifugation separates mononuclear cells from returning blood; product is characterised (CD3 count, viability) and shipped fresh or cryopreserved to manufacturing.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Plerixafor (Mozobil) is an injection given with G-CSF to flush stem cells out of the bone marrow into the blood so that enough can be collected for an autologous transplant in myeloma or lymphoma.
Query for this technology: (TITLE:"Apheresis and starting-material collection" OR ABSTRACT:"Apheresis and starting-material collection") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Apheresis and starting-material collection, not a curated reading list.
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Shares Terumo Blood and Cell Technologies, Autologous CAR-T manufacturing, batch by batch, CAR-T cell therapy and the tag supporting.
Shares Cryopreservation and cell-therapy cold chain, CAR-T cell therapy and the tag supporting.
Shares Cryopreservation and cell-therapy cold chain and the tag supporting.
Shares Cryopreservation and cell-therapy cold chain and the tag supporting.
Shares Autologous CAR-T manufacturing, batch by batch, TCR-T cell therapy, CAR-T cell therapy and the tag supporting.
Shares Fresenius Kabi and the tag supporting.