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Vaccines made from a patient's own antigen-presenting cells loaded with tumour proteins; sipuleucel-T for prostate cancer was the first approved, and newer versions are tested in brain and other cancers.
Dendritic cells present antigens to T cells. Sipuleucel-T, approved in 2010 for metastatic castration-resistant prostate cancer, loads the patient's antigen-presenting cells with a prostatic acid phosphatase fusion protein and reinfuses them, prolonging survival modestly. Later dendritic cell vaccines pulsed with tumour lysate or RNA have reached phase 3 in glioblastoma and are combined with checkpoint inhibitors, while off-the-shelf approaches try to target dendritic cells inside the body.
Leukapheresis harvests monocytes, which are matured into dendritic cells, loaded with antigen and reinfused to prime tumour-specific T cells.
Nothing in the corpus depends on this yet.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Adagloxad simolenin is OBI Pharma's vaccine against the tumour sugar Globo H, in the phase 3 GLORIA trial as adjuvant treatment for triple-negative breast cancer that expresses the antigen.
Query for this technology: (TITLE:"Dendritic cell vaccines" OR ABSTRACT:"Dendritic cell vaccines" OR TITLE:"Dendritic cell vaccine" OR ABSTRACT:"Dendritic cell vaccine" OR TITLE:"DC vaccine" OR ABSTRACT:"DC vaccine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Dendritic cell vaccines, not a curated reading list.
Shares IMPACT (sipuleucel-T), Sipuleucel-T, Prostate cancer.
Shares Diakonos Oncology, Glioma & glioblastoma.
Shares Diakonos Oncology, Glioma & glioblastoma.
Shares Sipuleucel-T, Prostate cancer.
Shares Sipuleucel-T, Prostate cancer.
Shares IMPACT (sipuleucel-T), Prostate cancer.
Shares IMPACT (sipuleucel-T), Prostate cancer.
Shares IMPACT (sipuleucel-T), Prostate cancer.