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Making cell therapies from a healthy donor or stem-cell line in advance, so patients get an off-the-shelf product instead of waiting weeks.
Off-the-shelf products use healthy-donor T or NK cells (Allogene, Caribou, Cellectis, Takeda/MD Anderson cord-blood NK) or induced pluripotent stem cell master banks (Fate Therapeutics, Century, Shoreline, Cellular Biomedicine) edited to avoid graft-versus-host disease and host rejection. Banking, donor eligibility, and comparability across thousands of doses from one bank are the manufacturing questions; durability of response is the clinical one.
A characterised master cell bank (donor or iPSC) is expanded, gene-edited to remove TCR and HLA class I, differentiated if needed, and cryopreserved in hundreds of doses per batch.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Query for this technology: (TITLE:"Allogeneic donor and iPSC master cell banks" OR ABSTRACT:"Allogeneic donor and iPSC master cell banks") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Allogeneic donor and iPSC master cell banks, not a curated reading list.
Shares Cryopreservation and cell-therapy cold chain, CAR-T cell therapy and the tag supporting.
Shares Cryopreservation and cell-therapy cold chain and the tag supporting.
Shares Cryopreservation and cell-therapy cold chain and the tag supporting.
Shares CAR-NK & CAR-macrophage, Allogeneic (off-the-shelf) cell therapy, CAR-T cell therapy and the tag supporting.
Shares Cryopreservation and cell-therapy cold chain, CAR-T cell therapy and the tag supporting.
Shares UCART19: the first gene-edited, donor-derived CAR-T cells in children and adults with relapsed B-cell ALL, CAR-T cell therapy and the tag supporting.
Shares CAR-NK & CAR-macrophage, CAR-T cell therapy and the tag supporting.
Shares CAR-T cell therapy and the tag supporting.