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Lipegfilgrastim (Lonquex) is a once-per-chemotherapy-cycle white cell booster used in Europe, similar to pegfilgrastim, for adults and children from two years old.
Lipegfilgrastim was authorised by the European Commission in July 2013 for reduction in the duration of neutropenia and the incidence of febrile neutropenia in adults treated with cytotoxic chemotherapy for malignancy (excluding CML and MDS), extended to children aged 2 and over in 2021, on phase 3 trials in breast cancer (non-inferior duration of severe neutropenia versus pegfilgrastim) and NSCLC (superior to placebo). It differs from pegfilgrastim in the site-specific enzymatic glycopegylation used to attach the polyethylene glycol chain. It is not approved in the US. Bone pain and musculoskeletal pain are the common adverse effects; splenic rupture and pulmonary adverse reactions are rare class risks. Marketed by Teva.
Backbone ribbon from PDB 1RHG. RCSB PDB 1RHG. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
The glycoPEG chain is not shown.
Filgrastim site-specifically glycopegylated at threonine 134; reduced renal clearance gives once-per-cycle dosing with neutrophil-mediated self-regulating elimination.
1.Lipegfilgrastim slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| EU | 2013 | Reduction in duration of neutropenia and febrile neutropenia after cytotoxic chemotherapy in adults (children from 2 years added 2021) |
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Query for this drug: (TITLE:"Lipegfilgrastim" OR ABSTRACT:"Lipegfilgrastim" OR TITLE:"Lonquex" OR ABSTRACT:"Lonquex") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Lipegfilgrastim, not a curated reading list.
Shares Pegfilgrastim, Growth factors: G-CSF and febrile neutropenia prevention and the tag supportive.
Shares Teva Pharmaceuticals, Pegfilgrastim, Growth factors: G-CSF and febrile neutropenia prevention and the tag supportive.
Shares Growth factors: G-CSF and febrile neutropenia prevention and the tag supportive.
Shares Teva Pharmaceuticals and the tag supportive.
Shares Pegfilgrastim, Growth factors: G-CSF and febrile neutropenia prevention.
Shares Pegfilgrastim, Growth factors: G-CSF and febrile neutropenia prevention.
Shares Pegfilgrastim, Growth factors: G-CSF and febrile neutropenia prevention.
Shares Pegfilgrastim, Growth factors: G-CSF and febrile neutropenia prevention.