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Oral glutamine, an amino acid that gut and mouth lining cells use for fuel, may reduce the severity of mouth ulcers during head and neck chemoradiation; mucositis guidelines suggest it for that use. Intravenous glutamine in transplant patients is not recommended, and evidence for preventing nerve damage is thin.
Glutamine is the main energy substrate of rapidly dividing enterocytes and oral mucosa. The 2020 MASCC/ISOO mucositis guidelines suggest oral glutamine for the prevention of oral mucositis in head and neck cancer patients receiving radiotherapy with chemotherapy, based on several small randomised trials, and recommend against parenteral glutamine in haematopoietic stem cell transplantation, where one trial suggested higher relapse. Trials of oral glutamine to prevent oxaliplatin and paclitaxel neuropathy are small and unblinded with inconsistent results, so it is not recommended for neuropathy. Glutamine is inexpensive and well tolerated; the theoretical concern that it feeds tumours has not been borne out clinically for oral use.
Supplying the preferred fuel of mucosal cells is proposed to speed epithelial repair after radiation and cytotoxic injury.
Query for this technology: (TITLE:"Glutamine for mucositis and neuropathy" OR ABSTRACT:"Glutamine for mucositis and neuropathy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Glutamine for mucositis and neuropathy, not a curated reading list.
Shares MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, Mucositis and stomatitis, Multinational Association of Supportive Care in Cancer, Evidence-based integrative oncology and the tags complementary, supportive-care.
Shares Peripheral neuropathy (chemotherapy-induced), Nerve damage from chemotherapy: what recovers, and what helps, Evidence-based integrative oncology, Oxaliplatin and the tags complementary, supportive-care.
Shares MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, Mucositis and stomatitis, Multinational Association of Supportive Care in Cancer, Evidence-based integrative oncology and the tags complementary, supportive-care.
Shares MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, Mucositis and stomatitis, Multinational Association of Supportive Care in Cancer, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Peripheral neuropathy (chemotherapy-induced), Nerve damage from chemotherapy: what recovers, and what helps, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Peripheral neuropathy (chemotherapy-induced), Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Multinational Association of Supportive Care in Cancer, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued, Head and neck squamous cell carcinoma and the tags complementary, supportive-care.